Yes, twice. First in late 1985, when it reached a sad #95 on the chart. I was honestly surprised that such a good record would chart so low.
Then in early 1986, Diana performed the 12-inch version when she hosted the American Music Awards. Perhaps thinking they could repeat what had happened the year before [[when the MISSING YOU video was shown on the AMAs and made the single hit the Pop Top 10), RCA released an edit of the 12-inch version of CHAIN REACTION as a single. It did slightly better than the original release, but still only reached #66.
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